Scientist/Senior Scientist, Protein Design Job at Systimmune, Redmond, WA

bk92bWpSMTd0ZXppazV1TUNVVzd0TFYwZmc9PQ==
  • Systimmune
  • Redmond, WA

Job Description

Job Description

Job Description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

SystImmune Inc. is looking for a creative and motivated Protein Design Scientist or Senior Scientist to work in our Computational Protein Design group. As part of the early scientific team, this individual will be involved in execute and improve the Computational Protein Design pipeline, using data-driven approaches to augment SystImmune Inc’s first-in-class multi-specific biological programs.

The ideal candidate will have industry experience applying computational methods to design novel peptides and proteins, such as structural modeling and prediction, structure library generation, molecular docking, and multiparameter molecular property optimization. A successful candidate will be an excellent collaborator working closely with our Antibody Discovery, Protein Engineering, and Immuno-oncology teams.

Responsibilities: 
  • Execute and improve a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody-based elements via data-driven approach
  • Drive assay validation, tech transfer, and development initiatives to maintain industry standards; Contribute within the computational protein design group to operate yeast display-based protein discovery platforms
  • Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process
  • Analyze, interpret, document and present data to the scientific and leadership team
  • Work within a collaborative, and interdisciplinary team to actively contribute to executing the vision of the company
Qualifications:
  • PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field.
  • 8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required.
  • Applying to solve problems related to peptide and protein design, modeling, and sequence/structure-function prediction, experienced with relevant macromolecular modeling software (i.e. AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger)
  • Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET).
  • Proven contribution to therapeutic antibody development and selection is desirable. Design and validate novel and biologically relevant antibodies is highly desirable.


Compensation and Benefits:
The expected base salary range for this position is $150,000 - $250,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.
While most offers typically fall within the low to mid-point of the range , we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

 
SystImmune is a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

 
We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

 
SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.

Powered by JazzHR

EpHd1JZ1ax

Job Tags

Similar Jobs

CBTS

Cyber Security Engineer (W2 Contract only) (Atlanta) Job at CBTS

 ...Typical Day in the Role Implement design reviews to evaluate security controls Identify and communicate opportunities to enhance...  ..., the security aspects thereof. Thorough understanding of information security principles, techniques, principles, policy frameworks... 

The University of Texas at Austin

Student Administrative Assistant (Receptionist) (Open to Work-Study and Non-Work Study) Job at The University of Texas at Austin

 ...Student Administrative Assistant (Receptionist) This is a part time student position at Texas Performing Arts. Both work study and non-work study students are encouraged to apply. Position is available to continue throughout student tenure. The Receptionist answers... 

Castlerock

Bookkeeper Job at Castlerock

 ...Nonprofit Bookkeeping/Accounting Position If you are experienced in nonprofit bookkeeping/accounting and if you are looking for the...  ...video, and in writing Comfortable working independently in a virtual office, and Proactive in asking questions and asking for help... 

Campus Service Groups

School Custodian Job at Campus Service Groups

 ...School Custodian Campus Services Group (CSG) is looking for a dedicated School Custodian to maintain a clean and safe environment within our facilities. In this role, you'll work closely with staff and students, ensuring the school meets high cleanliness standards.... 

HOSP GILBERT & BERGSTEN, A LAW CORPORATION

Litigation Attorney (4YR EXP REQ) Job at HOSP GILBERT & BERGSTEN, A LAW CORPORATION

*About us* We are professional and agile. Our work environment includes: * Modern office setting * Work-from-home days Our firm is looking for a Litigation Attorney to join our team. The ideal candidate will have 2 to 7 years insurance defense experience in...