Job Description

Overview

Neurocrine Biosciences is a leading neuroscience-focused biopharmaceutical company dedicated to relieving suffering for people with great needs. The Drug Metabolism and Pharmacokinetics (DMPK) team is seeking an experienced pharmaceutical scientist to lead the application of ADME science to advance the large molecule portfolio. You will serve as a technical leader within DMPK, engaging in experimental design and data interpretation across discovery and development, and representing DMPK on Research and Development teams to ensure timely dissemination of ADME information.

Responsibilities

• Act as a DMPK representative on project teams, providing scientific and strategic input
• Design, execute, and manage in vitro drug metabolism data, in vivo PK studies, and PK-PD studies
• Prepare data summaries and present results to peers, project teams, and leadership
• Oversee outsourcing partners of DMPK studies, ensuring adherence to contractual standards within budget
• Provide expert contributions to the preparation and review of regulatory submissions
• Integrate in vitro ADME, in vivo PK, and PK/PD endpoints with discovery biology data to define SAR and SPR to guide optimization
• Develop data visualization strategies to ensure consistent data interpretation across project teams
• Aid in ADME knowledge management
• Apply innovative mechanistic modeling approaches to translate and predict human PK, inform clinical plans, and support compound registration
• Mentor and supervise day-to-day work of less experienced team members

Qualifications

• BS/BA in biology, chemistry, or related science with 12+ years of hands-on DMPK experience focused on large molecule modalities, or MS/MA with 10+ years, or PhD with 4+ years (postdoc acceptable)
• Demonstrated ability to work with interdisciplinary teams
• Working knowledge of ADME and pharmacokinetics
• Solid understanding of organic/medicinal chemistry
• Strong written and verbal communication skills
• Ability to lead, guide, and influence teams in decision making
• Proficiency in analyzing and visualizing multi-dimensional scientific data
• Excellent project management and mentorship abilities
• Expertise representing large molecule DMPK on discovery teams
• Ability to work as part of and lead multiple teams
• Experience with PK/PD modeling and software such as R, Matlab, Python, SimCyp, WinNonLin, SimulationsPlus, Monolix, etc.
• Programming/scripting skills in Python, C/C++, or R
• Ability to build an external network and stay current with literature and science in the area

Salary and Benefits

• Base pay range: $128,200.00/yr - $185,900.00/yr
• Annual bonus target: 30% of base salary
• Equity-based long-term incentive program eligibility
• Benefits include retirement savings plan with company match, paid vacation/holiday/personal days, paid caregiver/parental and medical leave, and health coverage (medical, Rx, dental, vision)

EEO statement: Neurocrine Biosciences is an EEO/Disability/Vets employer. We are committed to a workplace of belonging, respect, and empowerment, and encourage applicants from diverse backgrounds.

About the role: For more information, visit neurocrine.com.

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